how long does prednisone stay in your system after taking for 7 days

Are you scrolling your finger on Google to know how long prednisone stays? Whether you are currently on medication or going to take it, the content can give you an informative and detailed overview, starting from the duration of prednisone's presence in your body to its effects on your body. 

Taking too many prednisolone tablets can harm you, so it's important to take prednisolone as your doctor has advised. With this in mind, let's start understanding prednisolone more. 

What Is Prednisone? 

It is an oral corticosteroid (“steroid”) medicine patients take to relieve inflammation and mollify immune system activity.

This prednisone can be categorized under drugs known as glucocorticoids. It is available in tablets, oral solutions, and injectable formulations. This medicine is given to treat diseases like:

Health Condition  Use of Prednisone
Respiratory Illness  Asthma – Chronic Obstructive Pulmonary Disease (COPD)
Chronic Inflammatory Diseases  Inflammatory Bowel Disease (IBD) – Rheumatoid Arthritis
Neurological Conditions  Myasthenia Gravis – Muscular Dystrophy
Kidney Diseases  Glomerulosclerosis
Organ Transplants  Prevention or Treatment of Organ Rejection
Upper Respiratory Tract Infection Various respiratory infections and diseases, such as pharyngitis, epiglottitis, and laryngotracheitis

How Long Does Prednisone Work In Your Body After Taking The First Dose? 

The doctor usually gives this tablet for a short duration, such as 7 days. Let’s clarify some important information here. 

When one takes prednisone, it works very quickly, within a few hours to days of taking your first dose. If it works well to alleviate your inflammation, then you will notice its effects within a few hours.

The duration prednisone takes to work depends upon certain criteria, such as:

  • One consumes this prednisone drug for a longer period; it just gives relief to your pain, but it can’t cure your disease. People suffering from pharyngitis, epiglottitis, and laryngotracheitis are on this medication for longer. 
  • Prednisone dose depends on the treatment duration. It can be 5 mg to 60 mg per day depending on the condition being treated.

To give quicker results and to dissolve in your bloodstream within 2 hours, the immediate-release prednisone formulation tablet or solution form is best. 

However, delayed-release tablets are in the body for about 6 hours. Prednisone should be consumed with food or milk to avoid an upset stomach. 

How Long Does Prednisone Stay After Taking For 7 Days?

According to, once a patient consumes prednisone, it can stay in the urine, blood, saliva, or hair from 16.5 hours to 22 hours. Let's see how long prednisone stays inside the human body:

  • Urinalysis: After consuming prednisone, it is excreted through urine. The source said it was detected in urine 24 hours after use. It was detectable for up to 18 hours after topical use (on the skin).
  • Blood Detection: When it comes to the bloodstream, how long does prednisone stay? The prednisone remains in the body for several days after stopping the use of prednisone.
  • Saliva Detection: Some research evidence says that prednisone remains in the saliva. But how much time this drug takes has yet to be clarified. However, through saliva tests, we can predict the steroid level, but we can't say how long prednisone stays.
  • Hair Detection: Are you wondering how does prednisone stay in your hair? It lasts for 1 to 3 months. Even sometimes, it can stay for weeks or months, depending on factors like the dose of prednisone and the person's weight. 

Factors Influencing the Duration of Prednisone in Your System:

Prednisone can remain inside the body depending upon various factors like:

  • Dosage.
  • Food that you consume.
  • Basal metabolic rate.
  • Weight.
  • Other prescription drugs you must be consuming (especially when it comes to hormone replacements).

Dose Of Prednisone One Should Take

As per the information, healthcare providers suggest that the common dose of immediate-release or delayed-release prednisone is just 5 to 60 milligrams (mg) daily. According to another source, take a single dose in a day just after your breakfast. 

For instance, if your health provider gives you 30 mg daily, it is advisable to consume 6 tablets (6 x 5mg) simultaneously after breakfast.

Note: Taking health care advice is strictly advisable! So, consulting is the best and safest option before taking any medicine.

How Long Will It Take Before the Effects of Prednisone Wear Off?

Once you consume prednisone and it dissolves in your body, it works out effectively, then it shows few side effects. The side effects can be observed up to 2 weeks after your last dose.

However, taking prednisone in the short term can show mild side effects such as:

  • Weight gain.
  • Moon face (appearance of swelling).
  • Heartburn.
  • Change in activity.
  • Changes in behavior.
  • Mood swings.
  • Dizziness.
  • Headache.

Experience severe symptoms like:

  • Visual disturbances.
  • Depression.
  • Muscle twitching.
  • Changes in blood pressure.
  • Changes in blood sugar.
  • Excessive weight gain.

If prednisone side effects prolong for those who are on this medication, immediately speak to your healthcare professional.

However, immediately stopping this medicine without consulting a doctor can cause a sudden drop in adrenal glands and can lead to life-threatening risks. 

Managing Prednisone Withdrawal: A Gradual Approach to Detoxification

The non-prescribed high doses of prednisone can have adverse effects. It might damage your adrenal glands, and glands create steroids naturally, such as adrenaline hormones, which play a crucial role in regulating blood pressure and heart rate.

So, it's important to detoxify this higher dosage from your body. The detoxification approaches include:

1. Consulting with Healthcare Professionals:

Once you start on a prednisone detoxification journey, it is important to seek healthcare professionals' advice. Your doctor will check certain criteria like:

  • Identify your medical history.
  • Evaluate the reasons for prednisone use.
  • Your doctor will offer a personalized plan for your health needs.

2. Gradual Tapering Strategies:

Gradually reducing the dose of prednisone is important. It helps to minimize the symptoms. Healthcare providers advise some tapering schedules that can lessen the dosage over time.

This process can help your body to adjust to the medication at lower levels without showing any adverse reactions. 

3. Monitoring and Managing Withdrawal Symptoms:

During the detoxification process, attentively observing withdrawal symptoms is important. Symptoms like fatigue, muscle pain, and joint discomfort may prevail.

So, to ease these common symptoms, your healthcare team will guide you on how to manage these adverse signs that your body is showing, and their advice and support will ensure a smoother transition and mitigate potential challenges.

4. Hydration as a Key Strategy:

Drink as much water as possible to excrete prednisone from the body. This drug has more chances to flush out urine. Staying hydrated is always the best way to wear off the drugs easily.

5. Balanced Diet and Fiber Intake:

While you are in the course of taking prednisone drugs for the first seven days, then always have a balanced diet rich in fiber. Eating high-rich fiber can help with digestion easily and avoid any gastrointestinal issues.

Consuming foods like fruits, vegetables, and whole grains helps to keep the bowel in proper movement. Eating all these foods can help to excrete prednisone from the body through the bowel. 

6. Regular Exercise for Metabolism:

Involve yourself in regular activity, which can boost your metabolism and allow your organs, such as the liver, to function properly.

As we know, the liver helps to excrete all toxins from the body when it functions well, and then it can flush the drugs easily. Doing regular exercise helps to break down and flush out the drug prednisone easily.  

Is Prednisone A Bad Steroid?

Whether consuming prednisone is a “bad” or “good” steroid is often considered depending upon the side effects and the circumstances we consume. To know, see the case study here:

A case study published by the National Institute of Health article Drug dependence involving prednisone shows that consuming prednisone long developed serious symptoms such as cataracts, diabetes mellitus, and cushingoid signs. 

So, finally, deciding whether it is a good or bad steroid depends upon various reasons. The case study clearly says that when it comes to long-term consumption of these drugs can pose any health issues. 

So, better as per the doctor's advice, one must consume. If symptoms persist, they might immediately go to the doctor rather than delay it. As we know, health is wealth: it should be prioritized more than others!


If you are searching for how long prednisone stays, this article will give you exact information about what prednisone is, its side effects, the best approaches to flush out this drug, and many more are revealed here.

You need to move your eyes up and down each section to know more details. Remember, when it comes to health, then consulting your doctor is a must.


1. Is seven days of prednisone safe?

Ans: Yes, seven days of prednisone is safe. It depends on dosage, duration, and health condition that needs to be treated. However, the dosage is adjusted depending on your healing response. 

2. How long do the effects of prednisone last after stopping?

Ans: The side effects, such as headache, heartburn, etc., can last a few days to a few weeks. However, if they are worsening, consult your healthcare provider. 

3. What is the worst side effect of prednisone?

Ans: Some severe side effects of prednisone include allergic reactions, infections, gastrointestinal issues, and elevated blood sugar, which may remain for a long time.

4. How long is prednisone effective?

Ans: Prednisone's effectiveness is for two to three hours. After you take it, it will be entirely removed from your body after 11 to 16.5 hours. 

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Oliver Nelson

Oliver Nelson is a New York based Health Specialist Writer who completed his graduation from Syracuse University back in 2015. His writings were published in the top Healthcare brands in the United States.

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